This estate embraces 26 bucolic acres on Woodas Creek, an estuary of the East River. Visitors will find beauty everywhere—from the winding allée of crepe myrtles that frame the driveway to mature gardens containing an extensive collection of specimen trees, camellias, boxwood, and perennials.

The vastness of the landscape lends itself to strolls punctuated with noteworthy outdoor features. There is a sculpture by the internationally-known artist Jun Kaneko, a small pavilion next to a lotus pool, and a central fountain in an oval garden depicting a boy riding a swan.

The three-story Federal-style home was built in 1927 by Edwin Treakle, affectionately known as “the Clam King,” who earned his fortune at the Fulton Fish Market in New York City. The classically elegant interior of Samarkand with its marble foyer, raised-panel wainscoting and coffered ceilings is the perfect backdrop for an eclectic art collection, including works by local and international artists.

In addition to...